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CD4+ T cell immunity is dependent on an intrinsic stem-like program

Recorded on Thursday, July 18, 2024, from 2:00 PM ET to 3:00 PM ET • Sponsored by AST's Community of Transplant Scientists (COTS)

"CD4+ T cell immunity is dependent on an intrinsic stem-like program"
(Nat Immunol. 2024 Jan;25(1):66-76. doi: 10.1038/s41590-023-01682-z. Epub 2024 Jan 2.)

In this article:
CD4+ T cells are central to various immune responses, but the molecular programs that drive and maintain CD4+ T cell immunity are not entirely clear. Here [the authors] identify a stem-like program that governs the CD4+ T cell response in transplantation models... [The authors'] findings unravel a stem-like program that controls the self-renewal capacity and effector differentiation potential of CD4+ TEP cells and have implications for T cell-related immunotherapies.

Speaker:
- Wenhao Chen, PhD • Houston Methodist Hospital, Houston, TX

Moderator:
- Miguel Fribourg, PhD • Icahn School of Medicine at Mount Sinai, New York, NY

Discussant:
- Xian Li, MD, PhD • Houston Methodist Hospital, Houston, TX

Drs. Chen and Li also provided follow-up written responses to several questions submitted during the webinar. These answers can be found here.

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